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For patients whose goals are sleep, longevity, and cellular renewal, that is a remarkably light commitment relative to the depth of the mechanism it targets

NCBI 13

Am J Clin Nutr 91(6):16341641 Barancewicz M (1971) Studies on ceruloplasmin in the course of normal pregnancy and in cases complicated by intrahepatic cholestasis

This information may then give rise on one hand to an interoceptive, anti-inflammatory feedback signal sent to the inflamed region via ANS-derived catecholamines and HPA axis-derived corticosteroids, and on the other hand, to the involvement of limbic and cortical brain regions, which modulate the interoceptive networks by involving emotion, memory and cognition

Cerebrospinal fluid-contacting neurons (CSF-cNs) located in the ependyma have bidirectional communication function between cerebralspinal fluid and brain parenchyma, and may participate in the pathway of iron-induced cognitive dysfunction through projected nerve fibers and transmitted factor, such as 5-hydroxytryptamine, etc

& Lai, M