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However, other PDZ-binding proteins are known to also regulate CFTR localization and function, including NHERF2 55,84 , CAL (CFTR-associated ligand) 85 , and CAP70 (CFTR associated protein) 86 Furthermore, other non-PDZ-dependent mechanisms may contribute, since the physiologic dimers of CFTR are assembled independently of either NHERF1 or NHERF2, thus leaving PDZ-domains available for other interactions 55

The 28-day shelf life reflects both peptide stability and microbial protection concerns

Oncogene 37 , 31833199 (2018)

doi: 10.1212/01.wnl.0000183063.99107.5c

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Importantly, these body weight changes were not attributable to differences in food intake across the groups, as all treatments showed similar food consumption patterns in both lean and obese mice