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In response to an increase in the cytosolic Ca 2+ concentration, the Gardos channel opens, resulting in the efflux of K + with subsequent hyperpolarization driving Cl - exit (through Cl - channels)

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Deficiency of intracellular glutathione can worsen oxidative stress and accelerate cellular death in diseases such as Alzheimer disease, Parkinson disease, liver disease, cystic fibrosis, sickle cell anemia, HIV/AIDS and diabetes

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