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Most herbal alternatives, including ingredients like chromium picolinate, garcinia cambogia, and conjugated linoleic acid, show modest effects in small studies but lack the sustained appetite suppression and metabolic changes documented in semaglutide trials

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"Anytime you're manipulating how much someone gets in, it's really hard to out-supplement and out-diet a deficit that's artificially created through an appetite suppressant," he says

While initially hypothesis-generating, these findings laid the groundwork for more comprehensive analyses