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Estrogen-driven collagen decline accelerates during perimenopause, and most users land here with substrate already more depleted at baseline

Accordingly, Calabrese et al

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To be more specific, the GLP-1 receptor with an attached GLP-1 molecule had the function of instantly hydrolyzing glycosylphosphatidylinositols (GPIs), which generated short-lived inositolphosphoglycans (IPGs), and promoted phosphatidylinositol-3 kinase (PI3K) and mitogen-activated protein kinase (MAPK) activities (35)

GLP-1 helps regulate blood sugar, reduce appetite, and slow gastric emptying