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Incubation of shelterin with an inactive compound ( 60 ) at the highest concentration of compound 40 tested (300 M) did not show any increase in the TRF1 peak (Supplementary Fig

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The LEADER and SUSTAIN-6 trials, which followed diabetic patients for 37 years on GLP-1 therapy, documented reduced heart attacks and strokes without accumulation of serious toxicity

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