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The most common adverse events are gastrointestinal: nausea (occurring in 12-33% of subjects depending on dose), diarrhea, constipation, and decreased appetite

Studies in both normal healing and delayed healing models have shown improvements in callus volume, mineralization, bone mineral content, rate of successful union, and mechanical strength at fracture sites

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They link distant tissues

Since current policies have insufficiently addressed people's willingness to change, it is time for public-health communities, decision-makers, and health experts to encourage people and patients on Healthy Eating & Active Living through professional guidance (370, 371)