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Regarding rosiglitazone, RCTs demonstrated a biochemical improvement in liver enzymes and glycemic control both in diabetic and non-diabetic patients with NAFLD, whereas evidence of histological improvement is less clear: results derived from different studies are controversial regarding the effect on steatosis, ballooning, and fibrosis [45, 46, 57, 58]

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As a lyophilised peptide, retatrutide must be stored at -20C and reconstituted carefully to preserve structural integrity