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However, critical regulatory constraints significantly limit the contexts in which these peptides may be used

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In contrast, the WT groups exhibited a milder alteration in gene expression, involving fewer than 500 genes, with a tendency towards downregulation

The mammalian sirtuins (Sirt1--Sirt7) participate in a number of cellular and physiological functions such as gene silencing, apoptosis, mitochondrial function, energy homeostasis, and longevity [237].Transgenic mice with overexpression of the sirt1 gene demonstrate decreased lipid-induced inflammation, improved glucose tolerance, and protection from hepatic steatosis when fed a high-fat diet [238]

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