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Their cardioprotective effects are similarly well established, with significant reductions in hospitalizations for heart failure and cardiovascular mortality, as evidenced in large trials like DAPA-CKD and EMPA-KIDNEY (166, 167)

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This impaired lactate metabolism could also disrupt the positive adaptations typically associated with regular physical activity, such as mitochondrial biogenesis (Li et al., 2022

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Is any of this a recommendation for human use