Extracellular HSPs can prime antigen-presenting cells, promote cytokine production (e.g., TNF-, IL-6), and contribute to the generation of autoantibodies (124132)
In pregnant rabbits given once weekly subcutaneous doses of 0.01, 0.03, or 0.1 mg/kg tirzepatide (0.01-, 0.06-, and 0.2-fold the MRHD) during organogenesis, pharmacologically mediated effects on the gastrointestinal system resulting in maternal mortality or abortion in a few rabbits occurred at all dose levels
Neuron 80 , 10391053 (2013)
When this happens, hair follicles temporarily pause growth and prepare to shed
Is that what's happening there
However, the triple-hormone receptor agonism of retatrutide may bring additional benefits, potentially leading to more improvements in these parameters