The tirzepatide doses of 10 and/or 15 mg demonstrated superiority compared to placebo for the coprimary endpoints percentage body weight reductions from baseline at week 72 and the proportion of patients achieving 5% body weight reduction at week 72
In clinical medicine, microdosing GLP-1s is not a formal category
Key findings l-NAME + magnesium-rats and l-arginine + magnesium-rats exhibited worsened severe muscle weakness and lesions, brain lesions, hypermagnesemia and serum enzymes values, with emerging hyperkalaemia
For patients with deteriorating mental status, consider aggressive hypertonic therapy to prevent herniation to buy time
With significant caloric restriction, studies show the body may reduce conversion of thyroid hormone T4 to the more active T3 form and alter sympathetic nervous system activity, both of which can influence heat production
Erratum in: Diab Vasc Dis Res