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Schafer and Buettner (Free Radical Biology and Medicine, 2001) formalised the GSSG/2GSH couple as a quantitative index of the cellular redox environment, a framework still used to describe redox state across proliferation, differentiation and apoptosis in cultured cells

Glutathione is, in general, well-tolerated by most individuals

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Long-term use sustains results, preventing rebound pigmentation when paired with sunscreen and antioxidants

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