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The efficacy and safety of tirzepatide, with a special focus on cardiovascular safety, were investigated in the 52-week SURPASS-4 trial testing tirzepatide versus insulin glargine in adults with T2D and a high cardiovascular risk under inadequate glycemic control at baseline on one to three oral glucose-lowering medications (metformin, sulfonylurea, SGLT-2 inhibitor) (54, 74)

This section delves into the mechanisms that make GLP-1 medications effective tools for weight management

So, maintaining adequate levels of glutathione is incredibly important

Maisel K, Reddy M, Xu Q, Chattopadhyay S, Cone R, Ensign LM, Hanes J

The goal is sustainable weight loss that can be maintained long term rather than dramatic short-term changes

However, there are some cases in which hed prescribe semaglutide instead, including if you: Have cardiovascular disease Prefer to take a pill form over injections Have liver fibrosis or metabolic dysfunction-associated steatohepatitis (MASH) Frequently asked questions Is tirzepatide better than semaglutide