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The cingulate cortex is involved in memory, emotions, depression, or action decision, and its hypometabolism have been observed in neurological and psychiatric diseases, such as Alzheimer, depression or internet gaming disorder (49)

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It has been shown to stimulate the production of extracellular matrix proteins and promote the growth of new blood vessels, both essential in tissue repair and regeneration

caloric restriction, low glucose availability, exercise, and ischemia, cells can promote sirtuins activation by increasing NAD + -production as previously described