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Sources: MHRA Drug Safety Update: Topiramate Pregnancy Prevention Programme and risks (20232024)

Additionally, there was no systematic measurement or control for tobacco use, despite evidence indicating that nicotine exerts an effect on GLP-1, which may contribute to reduced feelings of hunger [49]

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In the first study, (ONeil.P et al, 2018) participants were subject to a 52 week randomised trial to investigate how efficient Semaglutide injections were for weight loss when compared with Liraglutide injections and a placebo