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Pulse rate (PR) was higher at all PG plateaus by up to 11 bpm, systolic blood pressure (BP) at the target PG 100 mg/dL and 45 mg/dL was lower by up to 8 mmHg, and diastolic BP at the target PG 100 mg/dL was lower by ~4 mmHg with tirzepatide versus placebo ( Supplementary Figure S4 )

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Most patients experience peak nausea within the first 4872 hours after injection, with significant improvement by day 57 as their body adapts

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