A phase I safety study in healthy adults confirmed that subcutaneous MOTS-c injections at doses up to 10 mg produced no serious adverse events, with a pharmacokinetic profile supporting once-daily or every-other-day dosing [3]
Pregnancy testing for women of childbearing age, repeated monthly during treatment per the REMS program
Meanwhile, duloxetine, assessed for its analgesic potential, did not reduce general fatigue but resulted in notable improvements in mental fatigue, pain relief, and overall symptom perception compared to a placebo [192]
The capsule format delivers both compounds in a single consistent unit dose
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