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In non-mammalian models, exposure concentrations in food or media can reach the g/L range (e.g., 1040 g/L in Drosophila diet) [162]

That's a predictable result

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This directionality is consistent with concentration gradients

Patel KA, Bhatt MH, Hirani RV, Patel VA, Patel VN, Shah GB et al (2022) Assessment of potential drug-drug interactions among outpatients in a tertiary care hospital, focusing on the role of P-glycoprotein and CYP3A4 (retrospective observational study)