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Article References Running Head: Oxidants and Antioxidants Funding Support: This study was supported by the National Science Center, Poland (grant 2015/17/B/NZ5/01370)

Patients may prefer troches for convenience, ease of self-administration, and steady systemic effects that support overall tissue regeneration

Maintenance doses are typically 1 mg every 2-3 months for life High-dose oral therapy (1000-2000 micrograms daily) may be effective in selected patients with pernicious anaemia under clinical supervision, as passive diffusion can compensate for absent intrinsic factor, though this is not routine first-line treatment in the UK The water-soluble nature of B12 means that high-dose supplementation carries minimal risk of toxicity , making it a safe option for individuals with confirmed or suspected deficiency

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