The pathogenesis and the pathophysiology of sepsis is very complicated and multifaceted: numerous biological mechanisms, such as infection, inflammation, oxidative stress, immune system dysregulation, blood coagulation, endothelium dysfunction, tissue damage, elevated cellular death and/or apoptosis are involved during sepsis at tissue, cellular and molecular levels causing a damaging systemic reaction [379]
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An SOD1 deficiency enhances lipid droplet accumulation in the fasted mouse liver by aborting lipophagy
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SLC38A1 is overexpressed in various tumors such as melanoma (Xie et al., 2014), acute myeloid leukemia (Li Y