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doi:10.1002/14651858.CD010308.pub2

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**Estimating an *Overall Average* Rate (Use with Caution!):** While a fixed monthly number is unreliable, we *can* look at results from long-term clinical trials (like the SURMOUNT studies) to get a very rough idea of the *overall average* rate over many months: * **Trial Data:** These studies often run for 72 weeks (about 18 months) or longer