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That's also where diabetic peripheral neuropathy adds another layer of complexity impaired circulation and nerve signaling make the already-limited healing environment in foot tissue even harder to overcome without targeted support

These functions include augmentation of dendritic arborization and synaptogenesis, neurogenesis, facilitation of hippocampal long-term potentiation (LTP) and calcium signaling (hypothesized building blocks of memory consolidation), angiogenesis and facilitation of cerebral blood flow and cerebro protection

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[PubMed: 29494208] 245

These are the kinds of metabolic shifts that dramatically reduce cardiovascular risk and extend healthspan