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Cautions and precautions include: History of pancreatitis (discontinue if pancreatitis is suspected) Type 1 diabetes or diabetic ketoacidosis (not indicated) Severe gastrointestinal disease including gastroparesis Gallbladder disease (increased risk with GLP-1 therapy) Diabetic retinopathy (monitor for worsening with rapid glycaemic improvement, particularly with semaglutide) Regarding renal impairment , most GLP-1 agonists (semaglutide, liraglutide, dulaglutide) require no dose adjustment

The high production of ROS can induce autophagy, apoptosis and programmed necrosis in cells, resulting in DNA damage and skin barrier breakdown

Enkephalins are the physiological ligands of opioid receptors, and apart from their role in pain perception, they may benefit mood and reduce stress when upregulated [11]

Aging 12 (3), 20492069