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IGF-1 has been shown to improve mitochondrial function and transmembrane potential in a HFD-fed obese mouse model [183]

Some patients do make this switch under medical supervision

Reimer RA, Darimont C, Gremlich S, Nicolas-Mtral V, Regg UT, Mac K

however, across their eight PUF repeats, PUF-11 and PUF-3, differ by only a single amino acid from each other [(Haupt et al., 2020) see Supplementary Figure S2]