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During phase 3 trials, it was administered as a once-weekly injection just under the skin, most often in the abdomen, thigh, or upper arm

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This allows the glutathione to enter the bloodstream intact, where it can then be delivered directly to the cells that need it most, including those in the liver

Thus, an increase in NRF2 activity, reflected by induction of NRF2 target genes, likely represent an important mechanism mediating the protection seen in GCLM KO mice

By reducing oxidative stress and combating inflammation, glutathione can play a supportive role in the management of these conditions, potentially improving the quality of life for those affected