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Lievers assessed homocysteine levels in patients with MTHFR 677 and 1298 variants and found a significant increase in homocysteine levels with both MTHFR 677CT and 677TT, but no change in fasting or methionine loaded homocysteine levels with MTHFR 1298 mutations (5)

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Yan Y, Nguyen K, K-A D, Ueno N, Andreeff M , Battula VL

While no blinding was implemented, all measures were taken to minimize bias in data collection and analysis

D., Vangel, M., Gupta, A

Pro-inflammatory effects of indoxyl sulfate in mice: impairment of intestinal homeostasis and immune response