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The non-enzymatic system includes antioxidant molecules such as ascorbate (ASC), glutathione (GSH), tocopherols, proline, flavo- noids, carotenoids, phenolic compounds, cytochromes and polyamines (Ahmad et al
Blocking GSH synthesis in combination with JMF4073 depletes dTTP/dCTP pools to eradicate T315I-Bcr-Abl leukemia We hypothesize that reducing the GSH level to increase replication stress can render T315I-Bcr-Abl leukemia more susceptible to JMF4073 in vivo
Worse, it could be misleading, sending your research down a dead-end path that costs valuable time and resources
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