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b , Perturbation score for DRG neuronal subtypes at different timepoints after injection of autoantibodies in mice

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While cost is a factor, Al-Aly highlighted other concerns that prevent more patients from using the medication, such as side effects, patients' thinking the medication will not help them lose weight, and drug shortages

It also causes Zn(II) dissociation from zinc proteins like SOD-1 in EL-4 cells (Gruhlke et al

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Instead, research suggests it works by inhibiting Hepatocyte Growth Factor Activator Inhibitor (HAI-1), an enzyme that normally limits HGF activity