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Fractyl is presenting the latest results from its trial of a gene therapy called Rejuva in mice at the annual meeting of the Obesity Society, called ObesityWeek, which is being held in Atlanta this week

A 2021 study found that individuals on a higher dose of GLP-1 lost an average of 15% (34 lbs) weight loss, with 44% of that weight loss (15 lbs) coming from muscle (Wilding et al, 2021)

What weight loss outcome does the platform reference

Imbalance towards the GIP receptor, combined with distinct signaling properties at the GLP-1 receptor, together may account for the promising efficacy of tirzepatide as observed in various cell models, isolated islets, and perfused pancreas (86)

Weekly subcutaneous dosing remains adequate despite the moderately shorter duration compared to Semaglutide

Marso SP, Bain SC, Consoli A, et al