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Factors such as starting weight, dosage, diet, exercise, sleep quality, and consistency with treatment all influence results

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In the future, additional molecules with different mechanisms of action are expected to emerge, making genetic support even more important in guiding treatment selection, always in combination with the patients phenotype and clinical characteristics

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Partial enteral nutrition (PEN) has been demonstrated to modulate the composition of the gut microbiota, particularly by promoting the proliferation of short-chain fatty acid (SCFA)-producing bacteria and enhancing mucosal barrier function 208

In addition to being compared to other GLP-1 RAs, oral semaglutide has strong metabolic advantages compared to other established classes of oral antihyperglycemic agents (AHAs)