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These preclinical results led to a clinical trial in chronic lymphocytic leukemia (CLL), where chlorambucil-resistant patients achieved further remission through ethacrynic acid cotreatment with the alkylating agent (Petrini et al ., 1993)

HSP70s may control their own activity by changing conformation or joining into an oligomeric structure

In hyperthyroidism, elevated thyroid hormones suppress TSH, creating a dysregulated metabolic state

PMC 6714635

IF reduces total cholesterol synthesis by decreasing the expression of sterol regulatory element binding protein-2 (SREBP-2) [48]

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