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Figure 9: Chronic liver disease (steatosis, steatohepatitis, and cirrhosis, respectively, based on severity of progression) is associated with decreased harvesting of energy and increased production of reactive oxygen species (ROS)

The schedule and length of B12 shots depend on each patients needs

This depletion compromises the brains antioxidant defense, leading to increased oxidative damage and neuronal death

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When the body is at a lower weight, and you are no longer on the medication, your brain and body prioritize storing fat and see the decrease in calories as a sign of distress, which can mean you may still gain weight even if you continue habits you began while on medication, such as eating smaller portions