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Regarding IGF system gene expression, Igf1r mRNA expression increased significantly in Igf1r fl/fl mice upon experimental pulmonary metastasis, showing an efficient depletion in PBS- and LLC-challenged CreERT2 mice, as expected due to tamoxifen-mediated Igr1r gene depletion

Glomerular hyperfiltration in diabetes: mechanisms, clinical significance, and treatment

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Severe Hypokalemia: A Critical Drop in Potassium Levels One of the most serious complications of B12 replacement therapy in severe megaloblastic anemia (a type of anemia where blood cells are abnormally large) is the development of severe hypokalemia (dangerously low potassium levels in the blood)

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