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Studies of glucose metabolism have shown that low doses of DPP4i that reduce DPP-4 activity within the gut, but not meaningfully in the systemic circulation, are sufficient to improve glucose tolerance (19, 20)

However, weight loss isn't solely about reducing food intakeit also involves improving metabolic health , preserving muscle mass , and supporting psychological well-being , areas where exercise plays a vital role

However, its specificity for the fibrotic pathology of frozen shoulder makes it an important peptide to watch in this space