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The majority of the reported events occurred in patients who experienced gastrointestinal reactions leading to dehydration such as nausea, vomiting, or diarrhea [see Adverse Reactions (6.1)]

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This heterogeneity can manifest at multiple levelsmolecular, phenotypic, metabolic, and functionaland reflects both intrinsic genetic/epigenetic alterations and extrinsic microenvironmental influences