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Increased exposure to phthalates, as determined by urine phthalate levels, has been associated with increased menopausal symptoms and may contribute to earlier onset of menopause and premature ovarian insufficiency (premature menopause)

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At baseline and after one, three, six, and seven months, biological samples including blood, urine, and exfoliated buccal mucosal cells were collected

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10.1210/en.2012-1435 14 BeardJ

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The results showed a significant increase in the number of TUNEL-positive points in senescent endothelial cells treated with FOXO4-DRI

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