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Targeting lactate production and efflux in prostate cancer

Off (48 weeks): no administration, allowing a washout before any subsequent cycle

In contrast, the dimerization strength of other steroid receptors would not be sufficient to retain stable binding to selective AREs 45,49

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B vitamin status Vitamin B12 deficiency is a well-established cause of peripheral neuropathy, and several GLP-1 formulations now include B12 specifically because of concerns about nutritional status during weight loss