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So it follows that continuing treatment helps preserve weight loss over time. Mir Ali, MD In the other placebo-controlled trial, SURMOUNT-MAINTAIN, the researchers investigated the efficacy and safety of maximum tolerated dose (MTD) tirzepatide and a lower 5 milligram (mg) dose for maintaining body weight reduction in adults with obesity

Here we identified that depletion of alpha-ketoglutarate (KG) sensitizes HR-proficient cells to DNA damaging agents by metabolic regulation of histone acetylation

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Therefore, we wondered if lipid peroxidation, an -syn-independent pathological cell death mechanism, might be involved 24,25,26