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Skeletal muscle-specific overexpression of uncoupling protein 3 (UCP-3, an inner mitochondrial membrane transporter that dissipates mitochondrial proton gradients) protected against HFD-induced insulin resistance in skeletal muscle, enhanced energy expenditure, and reduced PKC activity and membrane-associated DAG levels [172]

In its advanced stages, lipedema can lead to severe impairment of mobility and significant reductions in quality of life [1]

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The abnormal expression of GPx2 was detected in different tumors, and GPx2 was up-regulated in colorectal cancer [51, 52] and down-regulated in prostate intraepithelial neoplasia [53], suggesting that GPx2 plays complex roles in tumorigenesis [23]

Intriguingly, knockdown of LDHA , an essential enzyme in lactate production, suppressed hypoxia-induced PASMC proliferation and migration

Shipton, M