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Clinical studies consistently show that most people who stop semaglutide or tirzepatide regain a substantial portion of the weight they lost and research suggests the regained weight is disproportionately fat rather than the lean muscle mass that may have been lost during treatment

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35 Furthermore, the RCT LIGHT-ON (NCT02147925) compared the effect of liraglutide, sitagliptin and insulin glargine, when added to metformin in diabetic patients, exhibiting statistically significant results, in favor of liraglutide and sitagliptin, regarding body weight, visceral adipose tissue and liver fat content reduction

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