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It can then cause dysfunction of these brain cells, including increasing microvascular endothelial cells permeability, leucocyte adhesion, procoagulant activity, and reducing the availability of nitric oxide through various biochemical pathways initiated by mitochondrial overproduction of reactive oxygen species (124)

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Mokarram P, Naghibalhossaini F, Saberi Firoozi M, Hosseini SV, Izadpanah A, Salahi H, Malek-Hosseini SA, Talei A, Mojallal M

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Electrophysiology Neurons were constantly perfused at 3 ml min 1 with heated (3032 C), gassed (95% O 2 , 5% CO 2 ) artificial cerebrospinal fluid (pH 7.4, 300305 mOsm) containing (in mM): 119 NaCl, 2.5 KCl, 1.3 MgCl 2 , 2.5 CaCl 2 , 26 NaHCO 3 , 1.3 NaH 2 PO 4 , 20 D-glucose and 0.5 sodium ascorbate

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