Case Study: Efficacy of Semaglutide and Tirzepatide in Mouse and Rat MASH Models WuXi Biologys in vivo pharmacology team assessed the efficacy of semaglutide and tirzepatide in mouse and rat MASH models
Other AEs reported with SGLT2i use include osmotic diuresis-related events and volume depletion-related hypotension, the latter of which tends to be more common in older adults, people with an eGFR of 3060 mL/min/1.73 m 2 , and in those taking loop diuretics [4]
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Injection formulations allow weekly or monthly dosing, supporting adherence but requiring comfort with injections
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Further post hoc analyses are underway, and the ongoing SURMOUNT-MMO trial will help clarify whether tirzepatide has cardiovascular benefits in people without CVD and in the wider population with obesity who have not developed type 2 diabetes
