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In the STEP 1 trial, Semaglutide 2.4 mg weekly produced an average weight loss of 14.9% at 68 weeks, versus 2.4% with placebo (Wilding et al., NEJM 2021

Despite these limitations, the current framework provides a robust first step toward a deeper understanding of mitochondrial adaptations to SDH-b dysfunction

B12 injections serve as effective replacement therapy when natural absorption is compromised

The popular 1.6 g/kg target equals about 0.73 g/lb, while 1 g/lb equals 2.2 g/kg

It can be used alone or in combination with other diabetes medications, such as metformin or sulfonylureas