284 , 285 More research is needed to validate preclinical Alzheimer's and determine how to measure it with biomarkers that conclusively represent Alzheimer's disease, as opposed to other dementiacausing diseases
In vitro and in vivo Down syndrome models revealed that supplementation of mice with low molecular weight antioxidants such as -tocopherol reduced the level of oxidative stress, attenuated degeneration of cholinergic neurons, and improved working memory (Lockrow et al
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