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It has been demonstrated that NRF2 over-activation may be therapeutically beneficial for ameliorating RA owing to its anti-inflammatory and anti-oxidative activity associated with limiting cytokine production, cartilage-matrix degradation, and bone resorption 63

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5 Discussion Multiple lines of evidence from cellular, animal, and clinical studies show that ferroptosis is involved in the occurrence and progression of DKD

The accumulation and metabolism of drugs in the liver can cause a variety of pathophysiologic complications