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However, differences did not achieve statistical significance

A Herxheimer reaction can temporarily intensify symptoms such as fatigue, pain, brain fog, dizziness, or flu-like illness after treatment begins

doi: 10.1016/j.biopha.2017.08.009

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The depolarization of membranes in smooth muscle, release of endothelin and reduced nitric oxide, vasoconstriction, and formation of free radicals may lead to cerebral vasospasm, a condition that determines the outcome of the patient