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Aberrant tonic inhibition of dopaminergic neuronal activity causes motor symptoms in animal models of Parkinsons disease

However, the CDK4/6i palbociclib acted antagonistically in all the tested cell lines (Supplementary Fig

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These agents also reduce the expression of pro-inflammatory enzymes (iNOS, COX-2) and cytokines (TNF-, IL-1, IL-6), while promoting macrophage polarization toward the anti-inflammatory M2 phenotype [149]