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Gradual escalation over 16-20 weeks

Specifically, we showed an inverse association between serum IGF-1 levels and stroke recovery, in agreement with a clinical study [24], highlighting the potential of determining serum IGF-1 levels at hospitalisation (corresponding to the sub-acute post-stroke IGF-1 levels in our study) as a biomarker for stroke outcome

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It has been reported that the myocardial infarction increases NOX2-derived ROS that activated apoptotic pathways such as Apoptosis signal-regulating kinase 1-p38 pathway ((ASK-1)-p38MAPK) and Ca 2+ /calmodulin-dependent protein kinase II (CAMKII)