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Conditions like Wilson's disease, a genetic disorder where the body cannot properly excrete excess copper, are an absolute contraindication

Lowering blood homocysteine with folic acid based supplements: meta-analysis of randomised trials

A 2025 European Journal of Clinical Nutrition commentary on the NICE guideline argued that the diagnostic threshold and clinical awareness still need to be tightened further, especially around pernicious anaemia, which is still under-recognised in primary care

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Treatment is 10 mg daily for 10 days, followed by 10 mg monthly for life

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